UMR 9019 - Genome Integrity & Cancers

The Genome Integrity and Cancers unit is a mixt structure of the CNRS, Gustave Roussy and Université Paris-Saclay. Its main research objective is to advance in the understanding of the pathways safeguarding genome integrity at the cellular, molecular, and systemic levels. Our research adresses molecular and cellular responses to DNA damage and the consequences of their alteration in cancer cells.

Director: Dr. Patricia Kannouche
Deputy Director: Dr. Gerard Mazón

Administrative manager: Christelle Bouchot

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Seminar | Matinée de l’Intégrité du Génome

Seminar "Functional Genomics of Microsatellite Unstable Tumors and Therapeutic Target Discovery" by Gabriele Picco (Sanger Institute) 11:00 05/12/2025 at Roger

Clara Basto, PhD student of the team of Gerard Mazón/Eric Le Cam under the supervision of Pauline Dupaigne has been

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation 17 Octobre 2025 à 11h30 - Salle Roger

Masato Kanemaki from the University of Tokyo. (NEW TIME!) Friday, 17 October at 10:30 at Salle Roger Monier

Christophe Massard DITEP – Drug Drug development department “Phase I in 2025” & Sergey Nikolaev New UMR – Cancer Data

December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of

"Intra-tumoral heterogeneity in small-cell lung cancer development and response to therapy" Julian Sage (Stanford University, US) 13/10/2025 at 16h Salle

Prochaine réunion d'unité 13/10/2025 Salle Roger Monier 13h30 Speaker: Nataliya PETRYK “ Revealing the mechanisms linking genome replication and epigenome

G. Matos Rodrigues co-authors this work led by the Schatz lab describing the roles of ELOF1 during somatic hypermutation and

G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by

AAPG 2026 of the ANR (1st phase) closing on 14th October

The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell

OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies

The ATR/Chk1 pathway regulates cell cycle progression, especially during DNA damage by inducing arrest for repair. Beyond damage response, Chk1

In this work, authored by G. Matos-Rodrigues. CRISPR-Cas9 nickases, were used to study how replication forks respond to single-strand DNA

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