All Publications & News
Re-investigating PLK1 inhibitors as antimitotic agents
Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently
Abasic site-peptide cross-links are blocking lesions repaired by AP endonucleases
A. Ishchenko participates in this study of the fate of the DNA-protein crosslinks generated by the activity of AP endonucleases
Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial
The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination
G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by
Changes in the architecture and abundance of replication intermediates at UV-stalled replication forks in human cells
This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge
Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis
The AOUFOUCHI team participate in this article : Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of
Monitoring Chk1 kinase activity dynamics in live single cell imaging assays
The ATR/Chk1 pathway regulates cell cycle progression, especially during DNA damage by inducing arrest for repair. Beyond damage response, Chk1
Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing
OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies
Histone Variants: Guardians of Genome Integrity
B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.
Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
Lead by the postdocs of Mazon's team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase
Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors
The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell
Emmanuelle Pessagué | SEMINAIRE SIRIC EPICURE
Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation 17 Octobre 2025 à 11h30 - Salle Roger
Séminaire | Auditions Chaires Fondation Gustave Roussy
GR wellcomes Lisa Mangiante and Elsa Bernard to give two talks for the selection of candidates to the "Chair Fondation
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