News

TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells

The Kannouche team contributed to this study, published in Cancer Cell (2026), reporting the results of the ICARUS-LUNG01 Phase II trial: Efficacy, Safety, and Biomarker Analysis of Datopotamab Deruxtecan in Advanced Non-Small Cell Lung Cancer. The study evaluates the clinical activity, safety profile, and predictive biomarkers associated with datopotamab deruxtecan in patients with advanced non-small cell lung cancer.

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Efficacy, safety, and biomarker analysis of datopotamab deruxtecan in advanced non-small cell lung cancer: ICARUS-LUNG01 phase 2 study

The Kannouche team contributed to this study, published in Cancer Cell (2026), reporting the results of the ICARUS-LUNG01 Phase II trial: Efficacy, Safety, and Biomarker Analysis of Datopotamab Deruxtecan in Advanced Non-Small Cell Lung Cancer. The study evaluates the clinical activity, safety profile, and predictive biomarkers associated with datopotamab deruxtecan in patients with advanced non-small cell lung cancer.

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16th 3R meeting

16th edition of the French 3R meeting “Replication, Recombination, Repair” We are happy to announce the opening of registrations for the 16th

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Next Thesis Defences

December 15th 2025: Clara Basto

Molecular study on the roles of RAD51 and its partner proteins in the management of arrested replication forks

(Mazon/Dupaigne Team)
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December 17th 2025: Basile Guignier

Role of REV3L, the catalytic subunit of DNA polymerase Zeta, in the stability of difficult-to-replicate sequences in mammals

(Kannouche Team)

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Next Unit Lab Meeting

Prochaine réunion d’unité

13/10/2025
Salle Roger Monier 13h30
Speaker: Nataliya PETRYK

“  Revealing the mechanisms linking genome replication and epigenome maintenance « 

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