Archives des Article - umr9019.com

TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells

The Kannouche team contributed to this study, published in Cancer Cell (2026), reporting the results of the ICARUS-LUNG01 Phase II trial: Efficacy, Safety, and Biomarker Analysis of Datopotamab Deruxtecan in Advanced Non-Small Cell Lung Cancer. The study evaluates the clinical activity, safety profile, and predictive biomarkers associated with datopotamab deruxtecan in patients with advanced non-small cell lung cancer.

Efficacy, safety, and biomarker analysis of datopotamab deruxtecan in advanced non-small cell lung cancer: ICARUS-LUNG01 phase 2 study

Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors

The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell carcinomas (RCC). The team identified a frameshift mutation in NBR1, a gene involved in autophagy. Their findings suggest NBR1 as a potential new RCC predisposition gene, pending further validation.

Changes in the architecture and abundance of replication intermediates at UV-stalled replication forks in human cells

This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge genome stability, managed by DNA damage tolerance (DDT) via TLS polymerases or recombination. Using electron microscopy, we show TLS polymerase η acts at replication forks to prevent gaps after UV damage. We outline a timeline of UV damage tolerance highlighting polη’s crucial role in DNA synthesis continuity.

SUMO-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells

In this article, the Mazon’s team PhD student H. Dorison goes deeper in the understanding of the SUMO-mediated regulation of the resolvase Yen1 in mitotic cells.

Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation

Lead by the postdocs of Mazon’s team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase protein pools to control mitotic crossove formation during DSB repair.