The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell carcinomas (RCC). The team identified a frameshift mutation in NBR1, a gene involved in autophagy. Their findings suggest NBR1 as a potential new RCC predisposition gene, pending further validation.
This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge genome stability, managed by DNA damage tolerance (DDT) via TLS polymerases or recombination. Using electron microscopy, we show TLS polymerase η acts at replication forks to prevent gaps after UV damage. We outline a timeline of UV damage tolerance highlighting polη’s crucial role in DNA synthesis continuity.
In this article, the Mazon’s team PhD student H. Dorison goes deeper in the understanding of the SUMO-mediated regulation of the resolvase Yen1 in mitotic cells.
Lead by the postdocs of Mazon’s team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase protein pools to control mitotic crossove formation during DSB repair.