All Publications & News

Human RAD52 stimulates the RAD51-mediated homology search

In a work led by A. Muhammad, a PhD student under P. Dupaigne supervision in the team, we show that

DES BUTS CONTRE LE CANCER

DES BUTS CONTRE LE CANCER - Des stars du football se mobilisent lors d’un match au profit de Gustave Roussy

Effect of Mismatch repair deficiency on metastasis occurrence in a syngeneic mouse model

This work, led by P. Laplante in Kannouche's team, shows how mismatch repair deficiency causes high mutation rates and microsatellite

Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

G. Matos Rodrigues co-authors this work led by the Schatz lab describing the roles of ELOF1 during somatic hypermutation and

7th German-french DNA repair Meeting

The 7th German-French DNA repair meeting will be held this November 5th-7th in Paris. The unit is this time involved

ANR AAPG 2026 closing on 14 October 2026

AAPG 2026 of the ANR (1st phase) closing on 14th October

Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial

The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a

Structure and repair of replication-coupled DNA breaks

In this work, authored by G. Matos-Rodrigues. CRISPR-Cas9 nickases, were used to study how replication forks respond to single-strand DNA

Retraite de l’unité 16 Octobre 2025

La retraite de l'unité aura lieu le 16 Octobre 2025 à la cité U (Fondation Deutsch de la Meurthe). RDV

Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination

G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by

Séminaire | Auditions Chaires Fondation Gustave Roussy

GR wellcomes Lisa Mangiante and Elsa Bernard to give two talks for the selection of candidates to the "Chair Fondation

Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing

OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies

Next Thesis Defences

December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of

Monitoring Chk1 kinase activity dynamics in live single cell imaging assays

The ATR/Chk1 pathway regulates cell cycle progression, especially during DNA damage by inducing arrest for repair. Beyond damage response, Chk1