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L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC
L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
B. Rondinelli co-authors this article of the D'Andrea lab describing the roles of EZH2 at stalled replication forks.
Effect of Mismatch repair deficiency on metastasis occurrence in a syngeneic mouse model
This work, led by P. Laplante in Kannouche's team, shows how mismatch repair deficiency causes high mutation rates and microsatellite
Next Thesis Defences
December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of
DES BUTS CONTRE LE CANCER
DES BUTS CONTRE LE CANCER - Des stars du football se mobilisent lors d’un match au profit de Gustave Roussy
DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection
C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene
Gustave Roussy Cancer Research Lectures | Reuben Harris
"DNA adducting carcinogens exacerbate APOBEC mutagenesis and carcinogenesis" Reuben Harris (UT San Antonio, US) 01/10/2025 at 11h Salle Pierre Denoix
Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial
The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a
Histone Variants: Guardians of Genome Integrity
B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.
Emmanuelle Pessagué | SEMINAIRE SIRIC EPICURE
Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation 17 Octobre 2025 à 11h30 - Salle Roger
Human RAD52 stimulates the RAD51-mediated homology search
In a work led by A. Muhammad, a PhD student under P. Dupaigne supervision in the team, we show that
Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemia
F. Rosselli's team shows in this article how abnormal p21 expression in Fanconi anemia (FA) contributes to bone marrow failure
Gustave Roussy Cancer Research Lectures | Julien Sage
"Intra-tumoral heterogeneity in small-cell lung cancer development and response to therapy" Julian Sage (Stanford University, US) 13/10/2025 at 16h Salle
Re-investigating PLK1 inhibitors as antimitotic agents
Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently