All Publications & News

DES BUTS CONTRE LE CANCER

DES BUTS CONTRE LE CANCER - Des stars du football se mobilisent lors d’un match au profit de Gustave Roussy

Monitoring Chk1 kinase activity dynamics in live single cell imaging assays

The ATR/Chk1 pathway regulates cell cycle progression, especially during DNA damage by inducing arrest for repair. Beyond damage response, Chk1

DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection

C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene

Changes in the architecture and abundance of replication intermediates at UV-stalled replication forks in human cells

This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge

Next Thesis Defences

December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of

Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing

OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies

Next Unit Lab Meeting

Prochaine réunion d'unité 13/10/2025 Salle Roger Monier 13h30 Speaker: Nataliya PETRYK “ Revealing the mechanisms linking genome replication and epigenome

Histone Variants: Guardians of Genome Integrity

B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.

Gustave Roussy Cancer Research Lectures | Reuben Harris

"DNA adducting carcinogens exacerbate APOBEC mutagenesis and carcinogenesis" Reuben Harris (UT San Antonio, US) 01/10/2025 at 11h Salle Pierre Denoix

Emmanuelle Pessagué | SEMINAIRE SIRIC EPICURE

Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation 17 Octobre 2025 à 11h30 - Salle Roger

L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC

L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025

Structure and repair of replication-coupled DNA breaks

In this work, authored by G. Matos-Rodrigues. CRISPR-Cas9 nickases, were used to study how replication forks respond to single-strand DNA

Seminar | Matinée de l’Intégrité du Génome

Seminar "Functional Genomics of Microsatellite Unstable Tumors and Therapeutic Target Discovery" by Gabriele Picco (Sanger Institute) 11:00 05/12/2025 at Roger

Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

N. Petryk co-authors this review of the mechanisms of DNA methylation in mammals and its biological importance.