All Publications & News

Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis

The AOUFOUCHI team participate in this article : Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of

Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial

The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a

Re-investigating PLK1 inhibitors as antimitotic agents

Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently

Christophe Massard and Sergey Nikolaev | Internal Seminars at Gustave Roussy

Christophe Massard DITEP – Drug Drug development department “Phase I in 2025” & Sergey Nikolaev New UMR – Cancer Data

DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection

C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene

Retraite de l’unité 16 Octobre 2025

La retraite de l'unité aura lieu le 16 Octobre 2025 à la cité U (Fondation Deutsch de la Meurthe). RDV

Next Thesis Defences

December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of

Clara Basto, prix Peters at the « Journées JJCC de la Fonation ARC »

Clara Basto, PhD student of the team of Gerard Mazón/Eric Le Cam under the supervision of Pauline Dupaigne has been

Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

The Gavet team developed a FRET-based sensor to specifically monitor Chk1 activity during replication stress (RS). Basal Chk1 activity during

L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC

L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

B. Rondinelli co-authors this article of the D'Andrea lab describing the roles of EZH2 at stalled replication forks.

Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients

This article is a collaboration of the Kannouche team with the Gustave Roussy's team of S. Nikolaev. Xeroderma pigmentosum (XP)

Gustave Roussy Cancer Research Lectures | Julien Sage

"Intra-tumoral heterogeneity in small-cell lung cancer development and response to therapy" Julian Sage (Stanford University, US) 13/10/2025 at 16h Salle

Histone Variants: Guardians of Genome Integrity

B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.