All Publications & News
Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors
Beatrice Rondinelli co-authors a study revealing that pediatric high-grade gliomas (pHGG) with H3.3 mutations exhibit aberrant DNA repair promoting genome
Monitoring and quantifying replication fork dynamics with high-throughput methods
The N. Petryk lab highlights in this work advances in quantitative technologies that deepen understanding of chromosome replication beyond DNA
Restriction of Ku translocation protects telomere ends
In a collaborative effort, the Mazon/Le Cam team used Cryo-EM to reveal how Rap1 inhibits Ku’s NHEJ activity at telomeres.
Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial
The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a
Thomas Lejour Thesis Defences
Title : “Study of the Links Between Apollo, DNA Repair, and the HIF Pathway in Renal Oncogenesis” December 8, 2026,
DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection
C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene
ANR AAPG 2026 closing on 14 October 2026
AAPG 2026 of the ANR (1st phase) closing on 14th October
Séminaire | Auditions Chaires Fondation Gustave Roussy
GR wellcomes Lisa Mangiante and Elsa Bernard to give two talks for the selection of candidates to the "Chair Fondation
Histone Variants: Guardians of Genome Integrity
B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.
Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
The Gavet team developed a FRET-based sensor to specifically monitor Chk1 activity during replication stress (RS). Basal Chk1 activity during
DES BUTS CONTRE LE CANCER
DES BUTS CONTRE LE CANCER - Des stars du football se mobilisent lors d’un match au profit de Gustave Roussy
Next Unit Lab Meeting
Prochaine réunion d'unité 13/10/2025 Salle Roger Monier 13h30 Speaker: Nataliya PETRYK “ Revealing the mechanisms linking genome replication and epigenome
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TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells
The Kannouche team contributed to this study, published in Cancer Cell (2026), reporting the results of the ICARUS-LUNG01 Phase II