All Publications & News

Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial

The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a

7th German-french DNA repair Meeting

The 7th German-French DNA repair meeting will be held this November 5th-7th in Paris. The unit is this time involved

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

B. Rondinelli co-authors this article of the D'Andrea lab describing the roles of EZH2 at stalled replication forks.

Restriction of Ku translocation protects telomere ends

In a collaborative effort, the Mazon/Le Cam team used Cryo-EM to reveal how Rap1 inhibits Ku’s NHEJ activity at telomeres.

16th 3R meeting

Unit Seminar: Masato Kanemaki

Masato Kanemaki from the University of Tokyo. (NEW TIME!) Friday, 17 October at 10:30 at Salle Roger Monier

Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation

Lead by the postdocs of Mazon's team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase

Gustave Roussy Cancer Research Lectures | Julien Sage

"Intra-tumoral heterogeneity in small-cell lung cancer development and response to therapy" Julian Sage (Stanford University, US) 13/10/2025 at 16h Salle

Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors

The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell

Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination

G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by

L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC

L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025

Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients

This article is a collaboration of the Kannouche team with the Gustave Roussy's team of S. Nikolaev. Xeroderma pigmentosum (XP)

Human RAD52 stimulates the RAD51-mediated homology search

In a work led by A. Muhammad, a PhD student under P. Dupaigne supervision in the team, we show that

Staying true to yourself: mechanisms of DNA methylation maintenance in mammals

N. Petryk co-authors this review of the mechanisms of DNA methylation in mammals and its biological importance.