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Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis
The AOUFOUCHI team participate in this article : Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
N. Petryk co-authors this review of the mechanisms of DNA methylation in mammals and its biological importance.
Next Unit Lab Meeting
Prochaine réunion d'unité 13/10/2025 Salle Roger Monier 13h30 Speaker: Nataliya PETRYK “ Revealing the mechanisms linking genome replication and epigenome
Re-investigating PLK1 inhibitors as antimitotic agents
Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently
DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection
C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene
Séminaire | Auditions Chaires Fondation Gustave Roussy
GR wellcomes Lisa Mangiante and Elsa Bernard to give two talks for the selection of candidates to the "Chair Fondation
Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
Lead by the postdocs of Mazon's team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination
G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by
Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
The Gavet team developed a FRET-based sensor to specifically monitor Chk1 activity during replication stress (RS). Basal Chk1 activity during
Retraite de l’unité 16 Octobre 2025
La retraite de l'unité aura lieu le 16 Octobre 2025 à la cité U (Fondation Deutsch de la Meurthe). RDV
Clara Basto, prix Peters at the « Journées JJCC de la Fonation ARC »
Clara Basto, PhD student of the team of Gerard Mazón/Eric Le Cam under the supervision of Pauline Dupaigne has been
Abasic site-peptide cross-links are blocking lesions repaired by AP endonucleases
A. Ishchenko participates in this study of the fate of the DNA-protein crosslinks generated by the activity of AP endonucleases
L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC
L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025