All Publications & News

Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination

G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by

Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors

The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell

Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial

The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a

Monitoring Chk1 kinase activity dynamics in live single cell imaging assays

The ATR/Chk1 pathway regulates cell cycle progression, especially during DNA damage by inducing arrest for repair. Beyond damage response, Chk1

Histone Variants: Guardians of Genome Integrity

B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.

Monitoring and quantifying replication fork dynamics with high-throughput methods

The N. Petryk lab highlights in this work advances in quantitative technologies that deepen understanding of chromosome replication beyond DNA

DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection

C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene

Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemia

F. Rosselli's team shows in this article how abnormal p21 expression in Fanconi anemia (FA) contributes to bone marrow failure

Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation

Lead by the postdocs of Mazon's team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase

Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis

The AOUFOUCHI team participate in this article : Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of

Gustave Roussy Cancer Research Lectures | Reuben Harris

"DNA adducting carcinogens exacerbate APOBEC mutagenesis and carcinogenesis" Reuben Harris (UT San Antonio, US) 01/10/2025 at 11h Salle Pierre Denoix

Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing

OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies

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Structure and repair of replication-coupled DNA breaks

In this work, authored by G. Matos-Rodrigues. CRISPR-Cas9 nickases, were used to study how replication forks respond to single-strand DNA