All Publications & News
Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing
OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination
G. Matos Rodrigues co-authors this work led by the Schatz lab describing the roles of ELOF1 during somatic hypermutation and
Retraite de l’unité 16 Octobre 2025
La retraite de l'unité aura lieu le 16 Octobre 2025 à la cité U (Fondation Deutsch de la Meurthe). RDV
Clara Basto, prix Peters at the « Journées JJCC de la Fonation ARC »
Clara Basto, PhD student of the team of Gerard Mazón/Eric Le Cam under the supervision of Pauline Dupaigne has been
Unit Seminar: Masato Kanemaki
Masato Kanemaki from the University of Tokyo. (NEW TIME!) Friday, 17 October at 10:30 at Salle Roger Monier
Monitoring and quantifying replication fork dynamics with high-throughput methods
The N. Petryk lab highlights in this work advances in quantitative technologies that deepen understanding of chromosome replication beyond DNA
Human RAD52 stimulates the RAD51-mediated homology search
In a work led by A. Muhammad, a PhD student under P. Dupaigne supervision in the team, we show that
Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemia
F. Rosselli's team shows in this article how abnormal p21 expression in Fanconi anemia (FA) contributes to bone marrow failure
Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
The Gavet team developed a FRET-based sensor to specifically monitor Chk1 activity during replication stress (RS). Basal Chk1 activity during
Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis
The AOUFOUCHI team participate in this article : Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of
Emmanuelle Pessagué | SEMINAIRE SIRIC EPICURE
Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation 17 Octobre 2025 à 11h30 - Salle Roger
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
N. Petryk co-authors this review of the mechanisms of DNA methylation in mammals and its biological importance.
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination
G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by
Next Thesis Defences
December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of