All Publications & News
Seminar | Matinée de l’Intégrité du Génome
Seminar "Functional Genomics of Microsatellite Unstable Tumors and Therapeutic Target Discovery" by Gabriele Picco (Sanger Institute) 11:00 05/12/2025 at Roger
Retraite de l’unité 16 Octobre 2025
La retraite de l'unité aura lieu le 16 Octobre 2025 à la cité U (Fondation Deutsch de la Meurthe). RDV
Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors
The S. Gad group of Ishchenko team leads this work on a novel genetic condition linked to Hereditary renal cell
Unit Seminar: Masato Kanemaki
Masato Kanemaki from the University of Tokyo. (NEW TIME!) Friday, 17 October at 10:30 at Salle Roger Monier
Clara Basto, prix Peters at the « Journées JJCC de la Fonation ARC »
Clara Basto, PhD student of the team of Gerard Mazón/Eric Le Cam under the supervision of Pauline Dupaigne has been
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
B. Rondinelli co-authors this article of the D'Andrea lab describing the roles of EZH2 at stalled replication forks.
Histone Variants: Guardians of Genome Integrity
B. Rondinelli co-authors this review covering the diveristy of Histone varints and their importance for Genome Integrity.
Changes in the architecture and abundance of replication intermediates at UV-stalled replication forks in human cells
This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge
Gustave Roussy Cancer Research Lectures | Reuben Harris
"DNA adducting carcinogens exacerbate APOBEC mutagenesis and carcinogenesis" Reuben Harris (UT San Antonio, US) 01/10/2025 at 11h Salle Pierre Denoix
A look back at the event « DES BUTS CONTRE LE CANCER »
€34,000 raised for cancer research
Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
Lead by the postdocs of Mazon's team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase
Efficacy, safety, and biomarker analysis of datopotamab deruxtecan in advanced non-small cell lung cancer: ICARUS-LUNG01 phase 2 study
The Kannouche team contributed to this study, published in Cancer Cell (2026), reporting the results of the ICARUS-LUNG01 Phase II
Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of the Nfkbia-c-Rel axis
The AOUFOUCHI team participate in this article : Tet2 deficiency promotes IgG1+ B-cell expansion and differentiation blockade through deregulation of
Gustave Roussy Cancer Research Lectures | Julien Sage
"Intra-tumoral heterogeneity in small-cell lung cancer development and response to therapy" Julian Sage (Stanford University, US) 13/10/2025 at 16h Salle