All Publications & News

TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells

The Kannouche team contributed to this study, published in Cancer Cell (2026), reporting the results of the ICARUS-LUNG01 Phase II

Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

G. Matos Rodrigues co-authors this work led by the Schatz lab describing the roles of ELOF1 during somatic hypermutation and

Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial

The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a

Monitoring and quantifying replication fork dynamics with high-throughput methods

The N. Petryk lab highlights in this work advances in quantitative technologies that deepen understanding of chromosome replication beyond DNA

Re-investigating PLK1 inhibitors as antimitotic agents

Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently

Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

The Gavet team developed a FRET-based sensor to specifically monitor Chk1 activity during replication stress (RS). Basal Chk1 activity during

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Changes in the architecture and abundance of replication intermediates at UV-stalled replication forks in human cells

This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge

Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients

This article is a collaboration of the Kannouche team with the Gustave Roussy's team of S. Nikolaev. Xeroderma pigmentosum (XP)

A look back at the event « DES BUTS CONTRE LE CANCER »

€34,000 raised for cancer research

DCLRE1B/Apollo germline mutations associated with renal cell carcinoma impair telomere protection

C. Bories, a PhD student under F. Renaud supervision in the Ishchenko team, leads the study identifying germline Apollo gene

Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors

Beatrice Rondinelli co-authors a study revealing that pediatric high-grade gliomas (pHGG) with H3.3 mutations exhibit aberrant DNA repair promoting genome

Séminaire | Auditions Chaires Fondation Gustave Roussy

GR wellcomes Lisa Mangiante and Elsa Bernard to give two talks for the selection of candidates to the "Chair Fondation

L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC

L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025