All Publications & News

Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing

OK-seq is a technique that sequences strand-specific Okazaki fragments to map replication initiation and termination in mammalian genomes. It quantifies

Access to the Electron Microscopy Platform site and forms

Accéder à la page de la plateforme et aux formulaires de contact

Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination

G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by

Next Thesis Defences

December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of

Restriction of Ku translocation protects telomere ends

In a collaborative effort, the Mazon/Le Cam team used Cryo-EM to reveal how Rap1 inhibits Ku’s NHEJ activity at telomeres.

Retraite de l’unité 16 Octobre 2025

La retraite de l'unité aura lieu le 16 Octobre 2025 à la cité U (Fondation Deutsch de la Meurthe). RDV

Abasic site-peptide cross-links are blocking lesions repaired by AP endonucleases

A. Ishchenko participates in this study of the fate of the DNA-protein crosslinks generated by the activity of AP endonucleases

L’équipe des « Gardiens du Génome » finisse en 5ème place au tournoi KOC

L'équipe des "Gardiens du Génome" cartonne au KOC du 13/09/2025

Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

The Gavet team developed a FRET-based sensor to specifically monitor Chk1 activity during replication stress (RS). Basal Chk1 activity during

Monitoring Chk1 kinase activity dynamics in live single cell imaging assays

The ATR/Chk1 pathway regulates cell cycle progression, especially during DNA damage by inducing arrest for repair. Beyond damage response, Chk1

Unit Seminar: Masato Kanemaki

Masato Kanemaki from the University of Tokyo. (NEW TIME!) Friday, 17 October at 10:30 at Salle Roger Monier

SUMO-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells

In this article, the Mazon's team PhD student H. Dorison goes deeper in the understanding of the SUMO-mediated regulation of

Re-investigating PLK1 inhibitors as antimitotic agents

Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently

Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

G. Matos Rodrigues co-authors this work led by the Schatz lab describing the roles of ELOF1 during somatic hypermutation and