All Publications & News
Re-investigating PLK1 inhibitors as antimitotic agents
Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently
Human RAD52 stimulates the RAD51-mediated homology search
In a work led by A. Muhammad, a PhD student under P. Dupaigne supervision in the team, we show that
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination
G. Matos Rodrigues co-authors this work of the Sleckman lab on the roles of Senataxin and DNA-PKcs during DSB by
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
N. Petryk co-authors this review of the mechanisms of DNA methylation in mammals and its biological importance.
DES BUTS CONTRE LE CANCER
DES BUTS CONTRE LE CANCER - Des stars du football se mobilisent lors d’un match au profit de Gustave Roussy
7th German-french DNA repair Meeting
The 7th German-French DNA repair meeting will be held this November 5th-7th in Paris. The unit is this time involved
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
B. Rondinelli co-authors this article of the D'Andrea lab describing the roles of EZH2 at stalled replication forks.
Changes in the architecture and abundance of replication intermediates at UV-stalled replication forks in human cells
This is a collaborative effort of the Kannouche and Mazon/LeCam teams of the unit. DNA lesions during S phase challenge
Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limit crossover formation
Lead by the postdocs of Mazon's team, I. Talhaoui and M. Bernal, the article describes the regulation of Yen1 resolvase
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination
G. Matos Rodrigues co-authors this work led by the Schatz lab describing the roles of ELOF1 during somatic hypermutation and
Structure and repair of replication-coupled DNA breaks
In this work, authored by G. Matos-Rodrigues. CRISPR-Cas9 nickases, were used to study how replication forks respond to single-strand DNA
Next Unit Lab Meeting
Prochaine réunion d'unité 13/10/2025 Salle Roger Monier 13h30 Speaker: Nataliya PETRYK “ Revealing the mechanisms linking genome replication and epigenome
Patritumab deruxtecan in HR+HER2- advanced breast cancer: a phase 2 trial
The Kannouche team participate in this article presenting the results of the phase 2 ICARUS-BREAST01 study. The study showed a
Next Thesis Defences
December 15th 2025: Clara Basto Molecular study on the roles of RAD51 and its partner proteins in the management of